p62 in Cancer: Signaling Adaptor Beyond Autophagy

p62 app  The selective autophagy substrate p62 serves as a molecular link between autophagy and cancer Suppression of autophagy causes p62 accumulation and thereby Upon binding to its ligand, p62 acts as a modulator of macroautophagy, inducing autophagosome biogenesis Through these dual functions, cells

β‑asarone modulates Beclin‑1, LC3 and p62 expression to attenuate Aβ40 and Aβ42 levels in APPPS1 transgenic mice with Alzheimer's disease  p62 acts as a selective autophagy receptor that recognizes and shuttles ubiquitinated proteins to the autophagosome for degradation

In the present study, we analyzed the interaction between p62, an adapter protein, and an APP-related molecule, and found that p62 interacted with the C- macular degeneration and cancer in animals, and the possible application of p62 plasmid in other inflammation-associated diseases